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The bacterium most immediately associated with farts is Escherichia coli (E. coli). E. coli is a well-known resident of the human gut and is commonly associated with the production of hydrogen and carbon dioxide, two main gases in flatulence. It also participates in the formation of methane when other gut microorganisms interact. E. coli’s role in digestion and gas production makes it a “go-to” name when discussing flatulence. Additionally, while it isn’t the sole cause, E. coli is a prominent contributor to overall gas production in the intestines.