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The Black Death was a bubonic plague pandemic occurring in Europe from 1346 to 1353. One of the most fatal pandemics in human history, as many as 50 million people perished, perhaps 50% of Europe's 14th century population. Bubonic plague is caused by the bacterium Yersinia pestis and spread by fleas. One of the most significant events in European history, the Black Death had far-reaching population, economic, and cultural impacts.