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The first identified case of H5N1 avian influenza in humans was recorded in 1997 in Hong Kong. The virus infected 18 people, resulting in 6 deaths. The earliest known human case in this outbreak was a 3-year-old boy named Lam Hoi-Ka, who fell ill in May 1997 and eventually died. This was a pivotal moment in understanding the ability of avian influenza to jump from birds to humans, sparking global concern about its pandemic potential.